BIOTHERMODYNAMICS WORKSHOP PROGRAM

AUGUST 4
13:00 – 13:30	Workshop Registration - Hotel Ferradura - Búzios
13:30 – 14:30	CO WS 1 - Thermodynamic Measurement and Detection: Advanced Isothermal Titration Calorimetry Techniques Caleb McDonald, TA Instruments
14:30 – 15:30	CO WS 2 - Introduction to Isothermal Titration Calorimetry and Differential Scanning Calorimetry for the Life Sciences: Principles and Experimental Design Verna Frasca, GE Healthcare
15:30 – 16:00	Afternoon Break
16:00 – 17:00	CO WS 3 - Applications of ITC and DSC for Drug Discovery: Binding, Thermodynamics, and Stability Studies Verna Frasca, GE Healthcare
17:00 – 18:00	CO WS 4 - The Power of Microcalorimetry in the Characterization of Biopharmaceuticals Caleb McDonald, TA Instruments
18:00 – 19:00	Q & A Session on Microcalorimetric Methodology
Moderators: Carlos Montanari and David P. Remeta
AUGUST 5
08:00 – 08:15	Welcome Remarks Carlos Montanari - Universidade de Sao Paulo, Brazil
08:15 – 09:00	CO WS 5 - Calibration and Operation of NanoITCs for Determination of K, ΔH, and Stoichiometry Lee D. Hansen - Brigham Young University, U.S.A.
09:00 – 09:45	CO WS 6 - The Human 90kDa Heat Shock Protein Hsp90: A Target for Cancer Therapeutics. Carlos Ramos - UNICAMP, Brazil
09:45 – 10:15	Morning Break
10:15 – 11:00	CO WS 7 - PHYSICO-CHEMICAL CHARACTERIZATION OF THE E. coli L-ASPARAGINASE M. Lucia Bianconi - Universidade Federal do Rio de Janeiro
11:00 – 12:00	CO WS 8 - KEYNOTE LECTURE: Problems and Prospects in DNA Thermodynamics Peter L. Privalov - The Johns Hopkins University, U.S.A.
12:00 – 13:00	Luncheon Honoring Professor Peter L. Privalov
13:00 – 13:45	CO WS 9 - How Water can Influence the Thermodynamic Signature in Protein-Ligand Binding Gerhard Klebe - University of Marburg, Germany
13:45 – 14:30	CO WS 10 - Mapping the Thermodynamic Landscape of Fragment-Based Drug Discovery Glyn Williams - Astex Therapeutics Ltd., United Kingdom
14:30 – 15:00	Afternoon Break
15:00 – 15:45	CO WS 11 - Entropy-Enthalpy Compensation and Transduction: Insights from MolecularSimulations Michael K. Gilson - University of California - San Diego, U.S.A.
15:45 – 16:30	CO WS 12 - Calorimetry as a Tool for Understanding Biomolecular Interactions and an Aid to Drug Design John E. Ladbury – University of Texas M.D. Anderson Cancer Center, U.S.A.
16:30 – 17:30	Panel Discussion - Current Topics in Biothermodynamics
Moderators: David P. Remeta and Carlos Montanari